Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
نویسندگان
چکیده
منابع مشابه
Hypoxia-inducible transcription factors and their role in renal disease.
The 2 hypoxia inducible factors (HIF)-1alpha and HIF-2alpha are key mediators of cellular adaptation to hypoxia. They show a specific distribution pattern and possibly have complementary transcriptional targets in the kidney: HIF-1alpha is found mainly in tubular and HIF-2alpha in peritubular interstitial, endothelial, and glomerular cells. Both isoforms are regulated by oxygen-dependent hydrox...
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In the present study, the levels of the hypoxia-inducible factors (hif-1, hif-2) transcripts were evaluated during development of an ancient fish species, Beluga sturgeon (Huso huso) in a normal oxygen environment. The transcripts of hif-1, hif-2 were detected in all developmental time-points of H. huso from embryos to juvenile fish. Changes in normalized hif-1, hif-2 mRNA expression by using t...
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ژورنال
عنوان ژورنال: European Urology
سال: 2016
ISSN: 0302-2838
DOI: 10.1016/j.eururo.2015.08.007